| Titre : | Incidence of primary opportunistic infections in two human immunodeficiency virus-infected french clinical cohorts. (2001) |
| Auteurs : | Yazdan Yazdanpanah ; Serge Alfandari ; Geneviève Chêne ; Kenneth-A FREEDBERG ; Sue-J GOLDIE ; Elena LOSINA ; Catherine MARIMOUTOU ; Laurence-Dequae MERCHADOU ; Yves MOUTON ; Adavid PALTIEL ; Roger SALAMON ; George-Riii SEAGE ; Lisa SULLIVAN ; General Medicine Division and Partners Aids Research Center. Department of Medicine. Massachusetts General Hospital. Boston. MA. USA ; Service Universitaire des Maladies Infectieuses et du Voyageur. Centre Hospitalier de Tourcoing. Centre Hospitalier Régional Universitaire de Lille. Tourcoing. FRA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 30, n° 4, 2001) |
| Pagination : | 864-871 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; VIH ; Rétrovirus ; Virus ; Infection opportuniste ; Etude comparée ; Epidémiologie ; Incidence ; Homme ; France ; Europe ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 5CR0xsiT. Diffusion soumise à autorisation]. Background Clinical guidelines for the prevention of opportunistic infections in humar immunodeficiency virus (HIV) - infected individuals have been developed on the basis of natural history data collected in the USA. The objective of this study was to estimate the incidence of primary opportunistic infections in HIV-infectec individuals in geographically distinct cohorts in France. Methods We conducted our study on 2664 HIV-infected patients from the Tourcoing AIDS Reference Centre and the hospital-based information system of the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine enrolled from January 1987 tc September 1995 and followed through December 1995. We estimated : (1) CD4 adjusted incidence rates of seven primary opportunistic infections in the absence of prophylaxis for that specific infection or any antiretroviral drugs other thar zidovudine ; and (2) CD4 lymphocyte count decline. Results The highest incidence rates for all opportunistic infections studied occurred in patients with CD4 counts<200/mul. With CD4 counts<50/mul, the most common opportunistic infections were toxoplasmic encephalitis (12.6 per 100 person-years) and Pneumocystis carinii pneumonia (11.4 per 100 person-years). Mycobacterium tuberculosis was the least common opportunistic infection (<5.0/100 person-years) Even with CD4 counts>300/mul, cases of Pneumocystis carinii pneumonia ane toxoplasmic encephalitis were reported. The mean CD4 lymphocyte decline per month was 4.6 cells/mul. There was a significant association between HIV risk behaviour and the incidence of cytomegalovirus infection, between calendar year and the incidence of Pneumocystis carinii pneumonia, toxoplasmic encephalitis and Candida esophagitis, and between geographical area and the incidence of Pneumocystis carinii pneumonia and cytomegalovirus infection. (...) |
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