| Titre : | Uptake of screening and prevention in women at very high risk of breast cancer. (2001) |
| Auteurs : | D.G.R. EVANS ; C. BOGGIS ; A. HOWELL ; F. LALLOO ; A. SHENTON ; Department of Medical Genetics. St Mary's Hospital. Manchester. GBR |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 358, n° 9285, 2001) |
| Pagination : | 889-890 |
| Langues: | Anglais |
| Mots-clés : | Sein ; Dépistage ; Prévention santé ; Femme ; Homme ; Cancer ; Glande mammaire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS TOR0x5F6. Diffusion soumise à autorisation]. Management of women at high lifetime risk of familial breast cancer is hampered because of limited data concerning the appropriateness of treatment options. Over the past 8 years women at very high (>40%) lifetime risk of breast cancer have had the option of entering two chemopreventlon treatment trials, a magnetic resonance Imaging (MRI) breast screening study, or a risk-reducing mastectomy (RRM) study. Only 10% of eligible women have entered one of the chemotherapy trials with a similar proportion opting for RRM (>50% in mutation carriers) compared with 60% opting for MRI screening. Future chemotherapy trials will have to be designed to address this poor recruitment. |

