| Titre : | Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population : The Rotterdam Study. (1997) |
| Auteurs : | R.P. STOLK ; Ptvm DE JONG ; D.E. GROBBEE ; A. HOFMAN ; S.W.J. LAMBERTS ; H.A.P. POLS ; Department of Epidemiology and Biostatistics. Erasmus University Medical School. Rotterdam. NLD ; Department of Epidemiology and Public Health. Faculty of Medicine. Utrecht University. NLD ; Department of Medicine Iii. Erasmus University Medical School. Rotterdam. NLD |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 145, n° 1, 1997) |
| Pagination : | 24-32 |
| Langues: | Anglais |
| Mots-clés : | Diabète ; Obésité ; Tabagisme ; Hypertension artérielle ; Epidémiologie ; Prévalence ; Association ; Facteur risque ; Personne âgée ; Homme ; Adulte ; Europe ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST 2a2R0xZR. Diffusion soumise à autorisation]. To estimate the prevalence of glucose intolerance in the elderly, oral glucose tolerance tests were performed as part of the Rotterdam Study, a population-based study in subjects aged 55 years and over. The study population consisted of 2,668 men and 3,950 women. Diabetes mellitus was defined as the use of antidiabetes medication, or a random or post-load serum glucose level of 11.1 mmol/liter. Impaired glucose tolerance was defined as a post-load serum glucose between 7.8 and 11.1 mmol/liter. In men, the frequency of diabetes mellitus ranged from 5.9% in ages<60 years to 19.8% in ages>85 years, and in women from 3.8% in ages<60 years to 18.9% in ages>85 years ; more than half of the subjects with diabetes were newly diagnosed. The prevalence of impaired glucose tolerance ranged from 8.8% and 11.0% in men and women aged<60 years to 24.3% and 34.7% in men and women aged>85 years. The prevalence of diabetes mellitus in the total Rotterdam Study population of 7,439 elderly men and women was estimated to be 11.3% (95% confidence interval (CI) 10.5-12.0). Waist/hip ratio, systolic blood pressure, hypertension, and number of cigarettes smoked increased with a worsening of the glucose tolerance from normal, hyperinsulinemia, impaired glucose tolerance to diabetes in both men and women (p<0.01, adjusted for age). Body mass index was higher in subjects with glucose intolerance, but the frequency of obesity showed a relative decrease with worsening of glucose tolerance. (...) |
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