| Titre : | Whooping cough and Parkinson's disease. (1996) |
| Auteurs : | J. DE PEDRO-CUESTA ; V. ABRAIRA ; J. ALMAZAN ; G. GUDMUNDSSON ; A. LOVE ; I.J. PETERSEN ; H. TULINIUS ; J. VEIGA ; Department of Applied Epidemiology. National Centre for Epidemiology. Carlos Iii Institute of Health. Madrid. ESP ; Department of Neurology. National University Hospital. Reykjavik. ISL |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 25, n° 6, 1996) |
| Pagination : | 1301-1311 |
| Langues: | Anglais |
| Mots-clés : | Maladie Parkinson ; Coqueluche ; Bactériose ; Infection ; Facteur risque ; Homme ; Epidémiologie ; Islande ; Système nerveux [pathologie] ; Appareil respiratoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST R0x8ZfGI. Diffusion soumise à autorisation]. Background. We reported high levodopa use and prevalences of Parkinson's Disease (PD) in periodically, time-clustered, Icelandic cohorts born after major whooping cough epidemics (MWCE). Methods. In order to quantify a possible relationship between age at first post-birth MWCE and risk of PD we : 1) calculated cumulative incidences of PD during the period 1954-1963 in one-year Icelandic cohorts born between 1869 and 1927, using raw material from a reported survey ; 2) identified MWCE from 1869 onwards in Iceland ; 3) estimated cohort ages at onset of incidence period and at first MWCE ; and 4) combined the above-mentioned information using log-linear models. In addition, we studied the prevalence of levodopa users in Icelandic birth cohorts during a recent period. Results. The curves of the above-mentioned incidences and prevalences in one-year birth-cohorts showed : 1) a similar, age-related, inverted V profile ; and 2) a systematic notchy pattern, with peak values for one or both measurements for cohorts born during or after each of nine MWCE identified during the period 1869-1927. When 13 cohorts born in years with MWCE were excluded from the analysis, the risk of PD rose with age at first defined MWCE, with the linear increase being 8.4% per year (95% CI : - 0.1-18.3%). Conclusions. (...) |
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