| Titre : | Metabolic risk factors for cardiovascular disease in a working population : A retrospective cohort study. (1996) |
| Auteurs : | B. GUMBINER ; E.M. ANDRESEN ; M. BRYSON ; R. CASS ; F.T. HEARNE ; W.M. LEDNAR ; T.E. MICHAELSON ; Eastman Kodak Company. Rochester NY. USA ; University of Rochester. Rochester NY. USA |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 49, n° 3, 1996) |
| Pagination : | 267-271 |
| Langues: | Anglais |
| Mots-clés : | Appareil circulatoire [pathologie] ; Hypertension artérielle ; Glucose ; Lipide ; Facteur risque ; Homme ; Métabolisme [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST e8R0xt2c. Diffusion soumise à autorisation]. Risk factors for cardiovascular disease (CVD) appear to cluster in individuals, possibly because of a single, underlying metabolic disorder. We describe the prevalence of metabolic risk factors for CVD in a young working population and the tendency for individuals with some risk factors to acquire additional factors. This was a retrospective three-year follow-up study of baseline CVD risk factors assessing (1) incidence of risk factors and (2) fatal CVD. The study group consisted of 9,747 Eastman Kodak employees, who participated in a worksite-based cardiovascular screening program in Rochester, New York, which included a medical history, physical examination, and laboratory evaluation. Abnormal metabolic risk factors were defined as (1) an abnormal glucose value (fasting blood sugar greater than 115 mg/dl) ; (2) abnormal lipids (high-density lipoprotein cholesterol under 35 mg/dl in men or under 45 mg/dl in women ; or low-density lipoproteins of 160 or greater ; or triglycerides greater than 250 mg/dl), and (3) hypertension (blood pressure systolic above 160 mmHg ; or diastolic above 90 mmHg). Subjects were classified as having none, one, two, or all three risk factors. Prevalence of single risk factors were : hypertension 9.8%, abnormal lipids 22.6%, and abnormal glucose 1.5%. Combinations of two risk factors were greater than expected by chance (p<0.01). Individuals who started with one or more abnormal values tended to have an increased risk of developing others. (...) |
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