Titre :
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Serum albumin and physical function as predictors of coronary heart disease mortality and incidence in older persons. (1996)
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Auteurs :
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M.C. CORTI ;
J.M. GURALNIK ;
M.E. SALIVE ;
Epidemiology. Demography. And Biometry Program. National Institute on Aging. National Institutes of Health. Bethesda Maryland. USA
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Type de document :
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Article
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Dans :
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Journal of clinical epidemiology (vol. 49, n° 5, 1996)
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Pagination :
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519-526
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Langues:
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Anglais
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Mots-clés :
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Cardiopathie coronaire
;
Personne âgée
;
Homme
;
Mortalité
;
Epidémiologie
;
Facteur risque
;
Incidence
;
Etats Unis
;
Amérique
;
Appareil circulatoire [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST R0xLCpp3. Diffusion soumise à autorisation]. The role of traditional risk factors in predicting coronary heart disease (CHD) among men and women aged 65 years and over has been extensively debated, but the search for risk factors that are distinctive in the elderly is still ongoing. The relation of serum albumin levels and physical disability to risk of CHD morality and incidence was prospectively assessed in a cohort of 4116 men and women, aged 71 years and over, who were evaluated in 1987-1989 and followed for a mean of 4.0 years. Outcome events were based on death certificates and Medicare hospitalization records. Analyses were adjusted for major CHD risk factors. There were 275 CHD deaths (16.8/1000 person-years) among all participants and 503 incident (fatal and nonfatal) CHD events (39.4 per 1000 person-years) among participants free of prevalent CHD during the observation period. The relative risk (RR) of CHD morality for women with an albumin concentration43 g/liter (RR 2.5 ; 95% confidence interval [CI], 1.4-4.6). There was a significant and graded increase in CHD incidence with decreasing albumin concentration in women but not in men. The presence of physical disability doubled the risk of CHD mortality among both men and women, an increase in risk that was comparable to that imposed by a previous myocardial infarction and was independent of other coronary risk factors. (...)
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