| Titre : | Dietary antioxidants and cognitive function in a population-based sample of older persons : The Rotterdam Study. (1996) |
| Auteurs : | J.W. JAMA ; M.M.B. BRETELER ; J.H. DEN BREEIJEN ; D.E. GROBBEE ; A. HOFMAN ; L.J. LAUNER ; J.C.M. WITTEMAN ; Department of Epidemiology and Biostatistics. Erasmus University Medical School and the Netherlands Institute for Health Sciences. Rotterdam. NLD |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 144, n° 3, 1996) |
| Pagination : | 275-280 |
| Langues: | Anglais |
| Mots-clés : | Personne âgée ; Homme ; Epidémiologie ; Antioxydant ; Vitamine C ; Vitamine ; Prévention santé ; Europe |
| Résumé : | [BDSP. Notice produite par INIST DR0x4hfC. Diffusion soumise à autorisation]. Antioxidants have been implicated in processes related to atherosclerosis, aging, and selective neuronal damage, all of which may ultimately affect cognitive function. In a sample of older persons, the authors examined the cross-sectional relation between cognitive function and dietary intake of bêta-carotene and vitamins C and E. The data were derived from 5,182 community participants aged 55-95 years in the population-based Rotterdam Study in the period 1990 to 1993. Dietary intake was estimated from a semiquantitative food frequency questionnaire and categorized into five levels of intake. Cognitive function was measured with the 30-point Mini-Mental State Examination (MMSE) and characterized as unimpaired (>25 points) or impaired ( 25 points). Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (Cl) for cognitive impairment. After adjustment for age, education, sex, smoking, total caloric intake, and intake of other antioxidants, a lower intake of bêta-carotene was associated with impaired cognitive function (<0.9 mg vs. 2.1 mg intake, OR=1.9,95% Cl 1.2-3.1 ; p for trend<0.04). There was no association between cognitive function and intake of vitamins C and E. These cross-sectional observations are compatible with the view that bêta-carotene-rich foods may protect against cognitive impairment in older people. (...) |
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