| Titre : | Prospective study of relative weight and risk of breast cancer : The breast cancer detection demonstration project follow-up study, 1979 to 1987-1989. (1996) |
| Auteurs : | L.C. YONG ; C.C. BROWN ; C. SCHAIRER ; A. SCHATZKIN ; Division of Cancer Prevention and Control. National Cancer Institute. Bethesda MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 143, n° 10, 1996) |
| Pagination : | 985-995 |
| Langues: | Anglais |
| Mots-clés : | Obésité ; Epidémiologie ; Femme ; Homme ; Cancer ; Sein ; Poids corporel ; Ménopause ; Age ; Etude prospective ; Etats Unis ; Amérique ; Glande mammaire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST afBuR0xw. Diffusion soumise à autorisation]. Despite extensive research on obesity and breast cancer in recent decades, inconsistencies in the literature exist. The authors examined prospectively the relation between adult relative weight (weight (kg)/height (m) 1.5) and breast cancer risk in a cohort of 54,896 women aged 31-89 years who had previously participated in the Breast Cancer Detection Demonstration Project. During a mean follow-up period of 7 years, 226 of the premenopausal women and 1,198 of the postmenopausal women developed breast cancer. Analysis was performed using Cox proportional hazards regression methods with age as the underlying time variable and adjusted for the effects of potential confounders. Among postmenopausal women, the risk of breast cancer increased with increasing relative weight (p<0.05 for trend) ; relative risk for the highest compared with the lowest quintile for relative weight was 1.3 (95% confidence interval (CI) 1.1-1.6). This association was modified by age at diagnosis, with relative risks of 1.1 (95% CI 0.8-1.4), 1.2 (95% CI 0.8-1.7), and 1.8 (95% CI 1.3-2.5), respectively, for women aged<60,60-64, and 65 years. The higher risk of breast cancer among the older and overweight women was largely confined to women whose weights were measured during the postmenopausal but not the premenopausal period. This risk pattern was observed among the naturally menopausal women, but was also apparent in the smaller group of women with bilateral oophorectomy or hysterecto... |
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