| Titre : | Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation : The Linxian nutrition intervention trial. (1996) |
| Auteurs : | S.D. MARK ; L.I. BING ; W.J. BLOT ; S.M. DAWSEY ; Jfjr FRAUMENI ; Wang GUO-QING ; L.I. JUN-YAO ; P.R. TAYLOR ; G.U.O. WANDE ; Wang WEN ; National Cancer Institute. Bethesda MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 143, n° 7, 1996) |
| Pagination : | 658-664 |
| Langues: | Anglais |
| Mots-clés : | Hypertension artérielle ; Accident cérébrovasculaire ; Epidémiologie ; Thérapeutique médicamenteuse ; Vitamine ; Thérapeutique ; Antioxydant ; Milieu rural ; Chine ; Asie ; Homme ; Mortalité ; Appareil circulatoire [pathologie] ; Système nerveux [pathologie] ; Vaisseau sanguin encéphale [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST 19xR0xZG. Diffusion soumise à autorisation]. A total of 3,318 men and women from a region in rural China were randomized to receive daily either a multiple vitamin/mineral supplement or a placebo. Deaths that occurred in the participants were ascertained and classified according to cause over the 6-year period from 1985 to 1991. At the end of supplementation, blood pressure readings were taken, and the prevalence of hypertension was determined. There was a slight reduction in overall mortality in the supplement group (relative risk (RR)=0.93,95% confidence interval (Cl) 0.75-1.16), with the decreased relative risk most pronounced for cerebrovascular disease deaths (RR=0.63,95% Cl 0.37-1.07). This benefit was greater for men (RR=0.42,95% Cl 0.19-0.93) than for women (RR=0.93,95% Cl 0.44-1.98). Among the survivors, the presence of elevations in both systolic and diastolic blood pressures was less common in those who received the supplement (RR for men=0.43,95% CI 0.28-0.65 ; RR for women=0.92,95% Cl 0.68-1.24). This study indicates that supplementation with a multivitamin/mineral combination may have reduced mortality from cerebrovascular disease and the prevalence of hypertension in this rural population with a micronutrient-poor diet. |
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