| Titre : | Timing and patterns of exposures during pregnancy and their implications for study methods. (1996) |
| Auteurs : | I. HERTZ-PICCIOTTO ; J.J. BEAUMONT ; L.M. PASTORE ; Department of Epidemiology. School of Public Health. University of North Carolina at Chapel Hill. Chapel Hill NC. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 143, n° 6, 1996) |
| Pagination : | 597-607 |
| Langues: | Anglais |
| Mots-clés : | Epidémiologie ; Méthodologie ; Grossesse ; Prévalence ; Exposition professionnelle ; Condition vie ; Elément environnement |
| Résumé : | [BDSP. Notice produite par INIST sfH8PR0x. Diffusion soumise à autorisation]. Patterns of exposure variability across pregnancy were examined for medical, lifestyle, residential, and occupational exposures in a population-based sample of 357 livebirths from 10 rural California counties. A new measure of variability, the ratio of overall prevalence to time-window-specific prevalence, is introduced. The higher the overall : time window (OTW) ratio, the greater the potential for misclassification when using anytime-during-pregnancy prevalence for an agent that exerts its effect in a smaller time window. Exposures to cigarettes, marijuana, saunas/hot tubs, factors related to location of residence, and some workplace substances tended to be of longer duration. Intertrimester concordance was high (kappa's>0.8) for smoking, residential proximity to crops, and use of video display terminals ; moderately high (kappa's between 0.4 and 0.8) for many occupational exposures ; and low (kappa's<0.4) for illnesses, which tended to be of short duration. The lowest OTW ratios were for smoking and some residential exposures (1.1-1.3), while OTW ratios were much higher for paint applications, influenza, vaginal infections, and ultrasound (reaching, e.g., 4-6). Use of anytime-during-pregnancy exposure indices can bias measures of association between risk factors and adverse pregnancy outcomes, particularly if the OTW ratio is high. Misclassification bias occurs if there is a vulnerable time window during which the exposure exerts its effect. The misclas... |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact