| Titre : | Breast cancer and lactation history in Mexican women. (1996) |
| Auteurs : | I. ROMIEU ; M. HERNANDEZ-AVILA ; E. LAZCANO ; L. LOPEZ ; R. ROMERO-JAIME |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 143, n° 6, 1996) |
| Pagination : | 543-552 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Sein ; Epidémiologie ; Allaitement ; Femme ; Homme ; Mexique ; Amérique ; Glande mammaire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST 7R0xeAWg. Diffusion soumise à autorisation]. The authors conducted a case-control study in Mexico City between September 1990 and December 1992 to determine whether a dose-response relation could be observed between duration of lactation and the risk of breast cancer. Cases, women aged 20-75 years, were identified through six hospitals in Mexico City (n=349) and were interviewed to obtain data on risk factors for breast cancer, including a detailed history of lactation. Controls (n=1,005) were selected from the general population using the Mexican national sampling frame. Parous women who had ever lactated had a reduction in breast cancer risk (age-adjusted odds ratio (OR)=0.39,95% confidence interval (Cl) 0.25-0.62). A small decreasing trend of breast cancer risk in relation to duration of lactation (p<0.001) was observed. Compared with parous women who had never breast-fed, women who had breast-fed for 12-24 months had an age-adjusted odds ratio of 0.47 (95% CI 0.27-0.83). A stronger protective effect was observed with lactation duration for the first live birth among pre-and postmenopausal women (for 4-12 months of lactation, OR=0.56 (95 percent CI 0.32-0.96) and OR=0.48 (95 percent CI 0.29-0.81) in pre-and postmenopausal women, respectively). Adjusting for potentially confounding factors modified these results only slightly. The declining trend in fertility and lactation among Mexican women could lead to a major epidemic of breast cancer such as that observed in Western countries. |
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