| Titre : | Risk of dementia in patients with Parkinson's disease, epilepsy, and severe head trauma : a register-based follow-up study. (1995) |
| Auteurs : | M.M.B. BRETELER ; R.R.M. DE GROOT ; A. HOFMAN ; L.K.J. VAN ROMUNDE ; Erasmus univ medical school. Dep epidemiology. DR Rotterdam. NLD |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 142, n° 12, 1995) |
| Pagination : | 1300-1305 |
| Langues: | Anglais |
| Mots-clés : | Maladie Parkinson ; Epilepsie ; Traumatisme ; Epidémiologie ; Démence ; Facteur risque ; Personne âgée ; Homme ; Europe ; Age ; Sexe ; Système nerveux [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST 3aiR0xyz. Diffusion soumise à autorisation]. The authors investigated the risk of developing dementia for persons aged 50-75 years who suffered from Parkinson's disease, epilepsy, or severe head trauma. They compared the risk in this patient group with the risk in a reference group in a follow-up study based on the linked databases of three Dutch nationwide morbidity registers over the years 1980-1989. The overall relative risk of developing dementia within 8 years in patients with Parkinson's disease who were initially free of dementia was 3.0 (95% confidence interval (CI) 2.9-3.1). Risk was especially increased in younger Parkinson's disease patients (relative risk (RR)=13.2,95% CI 6.2-28.6). For patients with epilepsy, the overall relative risk was 1.5 (95% CI 1.4-1.7). Severe head trauma was not associated with an increased risk of dementia (RR=1.0,95% CI 0.9-1.1). These findings suggest that Parkinson's disease is an important risk factor for dementia, with a particularly high risk in young patients with Parkinson's disease. Patients with epilepsy may bear a moderately increased risk of developing dementia. This study does not support earlier findings in retrospective case-control studies of an increased risk of dementia in head trauma patients. |
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