| Titre : | Soluble tumor necrosis factor alpha receptors (sTNF-Rs) in HIV-1-infected intravenous drug users : Change in circulating sTNF-R type II level and survival for AIDS patients. (2000) |
| Auteurs : | F. AJELLO ; F. BONURA ; M. BRUNO ; R. LA LICATA ; M. LODATO ; N. ROMANO ; R. VALENTI ; F. Vitale ; Dipartimento di Igiene e Microbiologia "G D'Alessandro". Università degli Studi. Palermo. ITA |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 16, n° 3, 2000) |
| Pagination : | 209-216 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; VIH ; Rétrovirus ; Virus ; Toxicomanie ; Concentration ; Plasma sanguin ; Survie ; Epidémiologie ; Pronostic ; Toxicomane ; Homme ; Italie ; Europe ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST PR0xid60. Diffusion soumise à autorisation]. This study in intravenous drug users (IVDUs) investigated differences in serum soluble tumor necrosis factor types I and II (sTNFR-I and II) concentrations in HIV-1-infected IVDUs and controls. This study also investigated whether changes of sTNFRs concentration affect the risk of death among patients with AIDS. A cross-sectional study of 54 subjects with AIDS, 47 HIV-seropositive IVDUs, 47 HIV-seronegative IVDUs, and 21 healthy subjects showed that sTNFRs concentration increases from healthy controls to AIDS patients through HIV-seronegative and HIV-seropositive subjects (p<0.01). sTNFR-I concentration, however, was shown to be similar in HIV-seronegative IVDUs and healthy controls. In the longitudinal study, serum concentration of sTNFRs was determined near AIDS diagnosis in 21 IVDUs and 1 year later (start for the survival study). Cox proportional hazards regression was performed to assess the prognostic value of percent change of sTNFR level alone and in combination with T lymphocyte subsets, HIV-p24 anti-genemia and opportunistic infections for death within 240 days. Uni-and multivariate Cox modelling for dichotomised variables according to its median showed an increase of sTNFR-II by at least 30% to be single significant predictor of death : crude relative risk 3.69, p=0.03 ; adjusted relative risk 5.67, p=0.02. Mean survival was 126 days in 11 patients whose sTNFR-II level increased by at least 30%, and 176 days in 10 patients with less change in sTNFR-II (p=0. (...) |
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