| Titre : | Increase in fasting insulin and glucose over seven years with increasing weight and inactivity of young adults : The CARDIA Study. (1996) |
| Auteurs : | A.R. FOLSOM ; J.M. FLACK ; J.E. HILNER ; Drjr JACOBS ; P.J. SAVAGE ; D.E. Smith ; L.E. WAGENKNECHT ; S.P. WINKHART ; C. YUNIS ; Division of Epidemiology. School of Public Health. University of Minnesota. Minneapolis MN. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 144, n° 3, 1996) |
| Pagination : | 235-246 |
| Langues: | Anglais |
| Mots-clés : | Poids corporel ; Epidémiologie ; Insuline ; Glucose ; Taux ; Jeune adulte ; Homme ; Activité physique ; Race ; Sexe ; Etats Unis ; Amérique |
| Résumé : | [BDSP. Notice produite par INIST wR0xaTIa. Diffusion soumise à autorisation]. To characterize 7-year changes in fasting serum insulin and glucose concentrations, the authors analyzed population-based data on 3,095 nondiabetic black and white men and women who were initially aged 18-30 years in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Measurements were made of fasting insulin (by an assay with little cross-reactivity to proinsulin) and fasting glucose on frozen samples from baseline and Year 7 examinations. Over the 7-year period, mean fasting insulin increased 10-25%, mean fasting glucose increased 7-10%, and mean body mass increased 7-12% across the four race-sex-groups. The strongest predictor of both insulin increase and glucose increase was an increase in body mass over the 7 years. Adjusted for age and examination time period in race-sex-specific repeated measures analyses, fasting insulin increased longitudinally by approximately 5 muU/mL per 5 kg/m2 increase in body mass index (p<0.05). Adjusted for age and time period, fasting insulin increased over the 7 years by approximately 2.5 muU/mL per 0.08 unit increase in waist/hip ratio (p<0.05), although this association was much stronger cross-sectionally. In a similar model, each 100 unit decrease in physical activity longitudinally predicted a 0.1-0.2 muU/mL increase in fasting insulin (p<0.05 in black men only) ; this association was stronger and statistically significant in all race-sex-groups cross-sectionally. (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact