Résumé :
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[BDSP. Notice produite par INIST wR0xaTIa. Diffusion soumise à autorisation]. To characterize 7-year changes in fasting serum insulin and glucose concentrations, the authors analyzed population-based data on 3,095 nondiabetic black and white men and women who were initially aged 18-30 years in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Measurements were made of fasting insulin (by an assay with little cross-reactivity to proinsulin) and fasting glucose on frozen samples from baseline and Year 7 examinations. Over the 7-year period, mean fasting insulin increased 10-25%, mean fasting glucose increased 7-10%, and mean body mass increased 7-12% across the four race-sex-groups. The strongest predictor of both insulin increase and glucose increase was an increase in body mass over the 7 years. Adjusted for age and examination time period in race-sex-specific repeated measures analyses, fasting insulin increased longitudinally by approximately 5 muU/mL per 5 kg/m2 increase in body mass index (p<0.05). Adjusted for age and time period, fasting insulin increased over the 7 years by approximately 2.5 muU/mL per 0.08 unit increase in waist/hip ratio (p<0.05), although this association was much stronger cross-sectionally. In a similar model, each 100 unit decrease in physical activity longitudinally predicted a 0.1-0.2 muU/mL increase in fasting insulin (p<0.05 in black men only) ; this association was stronger and statistically significant in all race-sex-groups cross-sectionally. (...)
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