| Titre : | Which cholesterol level is related to the lowest mortality in a population with low mean cholesterol level : A 6.4-year follow-up study of 482,472 Korean men. (2000) |
| Auteurs : | Y.M. SONG ; JOOHON SUNG . (.) ; JOUNG SOON KIM . (.) |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 151, n° 8, 2000) |
| Pagination : | 739-753 |
| Langues: | Anglais |
| Mots-clés : | Cardiopathie coronaire ; Homme ; Cancer ; Foie ; Mortalité ; Epidémiologie ; Cholestérol ; Facteur risque ; Appareil circulatoire [pathologie] ; Appareil digestif [pathologie] ; Foie [pathologie] ; Lipide ; Côlon |
| Résumé : | [BDSP. Notice produite par INIST zq5dR0xt. Diffusion soumise à autorisation]. To evaluate the relation between low cholesterol level and mortality, the authors followed 482,472 Korean men aged 30-65 years from 1990 to 1996 after a baseline health examination. The mean cholesterol level of them was 189.1 mg/100 ml at the baseline measurement. There were 7,894 deaths during the follow-up period. A low cholesterol level (<165 mg/100 ml) was associated with increased risk of total mortality, even after eliminating deaths that occurred in the first 5 years of follow-up. The risk of death from coronary heart disease increased significantly in men with the highest cholesterol level (>252 mg/100 ml). There were various relations between cholesterol level and cancer mortality by site. Mortality from liver and colon cancer was significantly associated with a very low cholesterol level (<135 mg/100 ml) without any evidence of a preclinical cholesterol-lowering effect. With lengthening follow-up, the significant relation between a very low cholesterol level (<135 mg/100 ml) and mortality from stomach and esophageal cancer disappeared. The cholesterol level related with the lowest mortality ranged from 211 to 251 mg/100 ml, which was higher than the mean cholesterol level of study subjects. |
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