| Titre : | Underestimation of Mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel. (2000) |
| Auteurs : | Mde-L GARCIA-GARCIA ; S. BALANDRANO-CAMPOS ; E. DANIELS ; A. ESCOBAR-GUTIERREZ ; C. GARCIA-SANCHO ; M.E. MAYAR-MAYA ; M. PALACIOS-MARTINEZ ; A. PERUGA ; J.L. VALDESPINO-GOMEZ ; M. WEISSENBACHER ; Instituto Nacional de Diagnostico y Referencia Epidemiologicos Indre. MEX ; Instituto Nacional de Salud P blica. MEX |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 29, n° 2, 2000) |
| Pagination : | 369-375 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; Homme ; Tuberculose ; Bactériose ; Poumon ; Epidémiologie ; Prévalence ; Estimation ; Immunopathologie ; Appareil respiratoire [pathologie] ; Tuberculose pulmonaire |
| Résumé : | [BDSP. Notice produite par INIST 6qm0QR0x. Diffusion soumise à autorisation]. Background This study aimed to evaluate purified protein derivative (PPD) reactivity and its interrelationship with anergy panel and CD4+lymphocytes in HIV-infected subjects as compared to PPD reactivity in HIV-uninfected individuals in a tuberculosis endemic and high Bacillus Calmette-Guérin (BCG) coverage environment. Methods Clients of four Mexico City HIV detection centres were screened for HIV-1 antibodies (ELISA or haemagglutination, Western Blot) ; reactivity to PPD (Mantoux PPD, 5TU RT-23), Candida (1 : 1000,0.1 ml), and tetanus toxoid (10Lf, 0.1 ml) ; and CD4+T cells. Active tuberculosis was excluded. Informed consent was obtained. Results From 5130 clients 1168 subjects were enrolled ; of these 801 (68.6%) were HIV positive. Reactivity to PPD among HIV-positive subjects was found in 174 (22%), 261 (32.6%), and 296 (37%), at PPD cutoff levels of >=10 mm, >=5 mm, and >=2 mm as compared to 224 (61%) of 367 HIV-negative individuals'reactors to PPD (>=10 mm) (P<0.001). After exclusion of anergic individuals using two cutoff levels for cutaneous allergens (<=2 mm and <=5 mm), PPD reactivity between HIV-infected and uninfected individuals continued to be significantly different. Only HIV-infected individuals with CD4+T cells >=500 cells/mm3 had similar reactivity to PPD as HIV-uninfected individuals. Variables associated with PPD reactivity were CD4+T cell counts, BCG scar, HIV infection and age. (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact