| Titre : | Chlamydia pneumoniae serological status is not associated with asthma in children or young adults. (2000) |
| Auteurs : | G.D. MILLS ; J.P. FAWCETT ; G.P. HERBISON ; J.A. LINDEMAN ; M.R. SEARS |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 29, n° 2, 2000) |
| Pagination : | 280-284 |
| Langues : | Anglais |
| Mots-clés : | Asthme ; Enfant ; Homme ; Jeune adulte ; Epidémiologie ; Facteur risque ; Examen sérologique ; Bactérie ; Appareil respiratoire [pathologie] ; Bronchopneumopathie obstructive |
| Résumé : | [BDSP. Notice produite par INIST 7TR0xTR5. Diffusion soumise à autorisation]. Background The factors that cause the allergic sensitization and inflammation in asthma still remain to be clarified. A role for Chlamydia pneumoniae has been suggested although serological studies have produced conflicting findings. This study aims to clarify the relationship between asthmatic variables and C. pneumoniae serological status. Methods A case-control study was undertaken on an asthma-enriched subset from a longitudinal birth cohort. In all, 198 subjects (96 with self-reported asthma) had C. pneumoniae serology (microimmunofluorescence [MIF] IgG, IgA) undertaken at age 11 and age 21 and assessment made in relation to a number of asthma variables. Results The only statistically significant finding was in subjects self-reporting asthma at age 21 who had evidence of lower IgG titres (P=0.046), a finding in the opposite direction to that expected from the hypothesis. Subjects with high IgG titres (>=128) were less likely to have reported ever having asthma ; odds ratio (OR)=0.29, (95% CI : 0.10-0.87). No association existed between symptoms suggestive of asthma in the previous 12 months and either IgG (P=0.127) or IgA (P=0.189) antibody titres at age 21. Likewise, no association was found between symptoms suggestive of asthma in the previous two years and C. pneumoniae IgG antibody titre (P=0.81) at age 11. There was no evidence of an association with any of the other variables examined at either age 11 or age 21. (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
bibliotheque@ehesp.fr