| Titre : | Reproductive factors and risk of papillary thyroid cancer in women. (2000) |
| Auteurs : | M.A. ROSSING ; J.R. DALING ; L.F. VOIGT ; K.G. WICKLUND ; Department of Epidemiology. School of Public Health and Community Medicine. University of Washington. Seattle. WA. USA ; Program in Epidemiology. Division of Public Health Sciences. Fred Hutchinson Cancer Research Center. Seattle. WA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 151, n° 8, 2000) |
| Pagination : | 765-772 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Thyroïde ; Homme ; Femme ; Facteur sociodémographique ; Epidémiologie ; Facteur risque ; Allaitement ; Grossesse ; Glande endocrine [pathologie] ; Thyroïde [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST GyfFTR0x. Diffusion soumise à autorisation]. The authors conducted a population-based case-control study of 410 women residing in three counties in western Washington State who were aged 18-64 years when diagnosed with papillary thyroid cancer in 1988-1994 and 574 controls to assess the effects of pregnancy history and other aspects of reproductive life on risk of this disease. Among women aged 45-64, the authors observed no associations with number of live births, age at first live birth, or age at last live birth. Risk was somewhat increased in women<45 years who had given birth within the previous 5 years ; this association was most evident among women who reported that cancer symptoms had led to diagnosis. Among women who had given birth within the last 5 years, risk was greatest among those with two or more births during that time period (relative risk (RR)=4.2,95% confidence interval (Cl) : 2.0,8.9, relative to parous women whose last birth was>5 years before the reference date). Risk of thyroid cancer was also associated with lactation during the previous 5 years (e.g., RR=2.9,95% Cl : 1.5,5.5, among parous women who had breastfed >=12 months, vs. 0-1 months, during that interval). Our results suggest that thyroid stimulation during both pregnancy and lactation may result in a transient increase in risk of papillary thyroid cancer. |
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