| Titre : | The relation between apolipoprotein A-I and dementia : The Honolulu-Asia aging study. Commentary. (2007) |
| Auteurs : | Jane-S SACZYNSKI ; Lenore-J LAUNER ; Rita-L PEILA ; Beatriz-L Rodriguez ; SCARMEAS (Nikolaos) / disc. : USA. Taub Institute for Research in Alzheimer's Disease and the Aging Brain. Columbia University Medical Center. New York. NY. ; Lon White ; National Institute on Aging. Intramural Research Program. Laboratory of Epidemiology Demography and Biometry. Bethesda. MD. USA ; University of Hawaii at Manoa. John A Burns School of Medicine. Department of Geriatric Medicine. Honolulu. HI. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 165, n° 9, 2007) |
| Pagination : | 985-997 |
| Langues: | Anglais |
| Mots-clés : | Démence Alzheimer ; Asie ; Personne âgée ; Homme ; Vieillissement ; Lipide ; Epidémiologie ; Maladie dégénérative ; Système nerveux [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS H3wTAR0x. Diffusion soumise à autorisation]. The association between apolipoproteins and neurodegeneration is unclear. The authors examined the association of dementia with serum levels of apolipoprotein A-I (ApoA-l) alone and in combination with the apolipoprotein E genotype (ApoE). Subjects were Japanese-American men in Hawaii followed since 1965 in the Honolulu Heart Program cohort and the Honolulu-Asia Aging Study. Lipid levels were assessed in 1980-1982. Dementia was diagnosed in 1991-1993,1994-1996, and 1997-1999 by using a multistep procedure and international guidelines. The sample consisted of 929 men (107 dementia cases). The relation between ApoA-I and dementia was examined by using Cox proportional hazards models adjusted for age, education, and cardiovascular risk factors. Compared with men in the lowest quartile, men in the highest quartile of ApoA-I concentration had a significantly lower risk of dementia (hazard ratio=0.25,95% confidence interval : 0.08,0.78). Compared with men with both risk factors, those with a high ApoA-l concentration and no ApoE epsilon4 had a significantly lower risk of dementia (hazard ratio=0.21,95% confidence interval : 0.08,0.52). Previous work has demonstrated an inverse relation between ApoA-1 and cardiovascular disease, and the authors extended these findings to the risk of dementia. These results raise the possibility that different lipoprotein components of cholesterol may be differentially associated with dementia. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact