Résumé :
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[BDSP. Notice produite par INIST-CNRS ZKR0xgM6. Diffusion soumise à autorisation]. Administration of human normal immunoglobulin (HNIG) post-exposure has been routinely used in Slovakia for outbreak control of hepatitis A, but requires deep intramuscular injection, provides only short-lived protection and is a human blood product. The protective effect of post-exposure administration of an inactivated hepatitis A vaccine was evaluated during 10 outbreaks in Slovakia. Direct contacts of confirmed hepatitis A cases received either : a single dose of hepatitis A vaccine (n=2171) or immunoglobulin (HNIG, n=3837). In the HNIG group the number of hepatitis A confirmed cases dropped within the first 7 weeks, however the decrease was not as rapid or as marked as that observed in the vaccinated group where the number of hepatitis A cases dropped within the first 4 weeks after vaccination. Among contacts, 67 cases of hepatitis A were detected during the maximum incubation period of 45 days : 16 cases (0.7%) in the vaccine group and 51 cases (1.3%) in the HNIG group (p
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