| Titre : | A prospective study of physical activity and risk of prostate cancer in US physicians. (2000) |
| Auteurs : | SIMIN LIU . (.) ; U. AJANI ; J.E. BURING ; C.H. HENNEKENS ; I.M. LEE ; P. LINSON ; Department of Epidemiology. Harvard School of Public Health. USA ; Division of Preventive Medicine. Department of Medicine. Brigham and Women's Hospital and Harvard Medical School. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 29, n° 1, 2000) |
| Pagination : | 29-35 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Prostate ; Homme ; Etats Unis ; Amérique ; Facteur risque ; Activité physique ; Appareil urinaire [pathologie] ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST 8Vi7R0xj. Diffusion soumise à autorisation]. Background Exercise can suppress androgen production and may thus decrease the risk of prostate cancer. However, findings from epidemiological studies assessing physical activity and risk of prostate cancer are inconsistent. Methods We prospectively examined the association between physical activity and prostate cancer risk in the Physicians'Health Study (PHS), a randomized trial of low-dose aspirin and beta-carotene among 22 071 men aged 40-84 without self-reported myocardial infarction, stroke and cancer. At baseline in 1982, men were asked about the frequency of exercise vigorous enough to work up a sweat. Physical activity was assessed in a similar fashion again at 36 months of follow-up. Results During 11.1 years of follow-up (258 779 person-years), 982 cases of prostate cancer occurred and were confirmed by medical record review. After adjustment for potential confounding factors (including age, height, randomized treatment assignment, smoking status, alcohol intake, use of multivitamins, history of diabetes, history of hypertension and history of high cholesterol), the relative risks for prostate cancer associated with exercise vigorous enough to work up a sweat were 1.0 (referent) for frequency less than once per week, 1.02 (95% CI : 0.82-1.26) for once per week, 1.07 (95% CI : 0.90-1.27) for 2-4 times per week, and 1.11 (95% CI : 0.90-1.36) for 5+times per week. (...) |
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