| Titre : | Serum carotenoids and markers of inflammation in nonsmokers. (2000) |
| Auteurs : | Stephen-B KRITCHEVSKY ; Andrew-J BUSH ; Myron D. Gross ; Marco PAHOR ; Department of Preventive Medicine. University of Tennessee. Memphis. Memphis. TN. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 152, n° 11, 2000) |
| Pagination : | 1065-1071 |
| Langues: | Anglais |
| Mots-clés : | Artériosclérose ; Homme ; Prévention santé ; Epidémiologie ; Régime alimentaire ; Alimentation ; Antioxydant ; Leucocyte ; Appareil circulatoire [pathologie] ; Vaisseau sanguin [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST 43cR0x78. Diffusion soumise à autorisation]. One explanation for discrepant results between epidemiologic studies and randomized trials of bêta-carotene and cardiovascular disease may be a failure to consider inflammation as a confounder. To evaluate the potential for such confounding, the authors relate the serum concentrations of five carotenoids (alpha-carotene, bêta-carotene, bêta-cryptoxanthin, lycopene, and lutein/zeaxanthin) to levels of three inflammatory markers (C-reactive protein, fibrinogen, and white blood cell count) measured during the Third National Health and Nutrition Survey, 1988-1994. The analysis included 4,557 nonsmoking participants aged 25-55 years. Adjusted concentrations of all five carotenoids were significantly lower in those with C-reactive protein levels above 0.88 mg/dl (p=0.001). There was a trend toward lower adjusted bêta-cryptoxanthin concentrations with increasing level of fibrinogen (p value test for trend=0.01), but other carotenoids were not related. Many of the carotenoid concentrations were lower among participants with high white blood cell counts. After log transformation, only adjusted mean bêta-carotene levels were significantly lower in those with white blood cell counts above 7.85 x 109/liter (p<0.01). (...) |
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