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Article
Hebe-N GOUDA ; HARDING (Anne-Helen) : GBR. Mrc Epidemiology Unit. Institute of Public Health. University of Cambridge. Cambridge. ; Julian-Pt HIGGINS ; Gurdeep-S SAGOO ; Manjinder-S SANDHU ; Jan Yates |[BDSP. Notice produite par INIST-CNRS R0xms9nG. Diffusion soumise à autorisation]. The peroxisome proliferator-activated receptor-gamma gene (PPARG) has been implicated in the etiology of type 2 diabetes mellitus and has been investigated in num[...]
Article
Muin-J KHOURY ; Jonine-L BERNSTEIN ; Lars BERTRAM ; Paolo BOFFETTA ; Paul-R BURTON ; Adam-S BUTTERWORTH ; Harry CAMPBELL ; Stephen-J CHANOCK ; Anand CHOCKALINGAM ; Siobhan-M DOLAN ; Isabel Fortier ; Helena FURBERG ; Montserrat GARCIA-CLOSAS ; Marta GWINN ; Julian-Pt HIGGINS ; John-Pa IOANNIDIS ; Acecile-Jw JANSSENS ; Julian LITTLE ; Thomas-R O'BRIEN ; James OSTELL ; Ryan-P OWEN ; Roberta-A PAGON ; Timothy-R REBBECK ; Nathaniel ROTHMAN ; Daniela SEMINARA ; Paolo VINEIS ; . WEI YU ; Deborah-M WINN ; Molecular Epidemiology Unit. University of Cambridge. Cambridge. GBR ; Office of Public Health Genomics. National Center for Chronic Disease Prevention and Health Promotion. Centers for Disease Control and Prevention. Atlanta. GA. USA |[BDSP. Notice produite par INIST-CNRS 8kmBtR0x. Diffusion soumise à autorisation]. Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new lo[...]
Article
Julian LITTLE ; Nick BIRKETT ; Barbara COHEN ; George DAVEY-SMITH ; Isabel Fortier ; Matthew FREEDMAN ; France Gagnon ; Jean GOLDING ; Jeremy GRIMSHAW ; . GUANG YONG ZOU ; Marta GWINN ; Julian-Pt HIGGINS ; Kim HUTCHINGS ; Claire INFANTE-RIVARD ; John-Pa IOANNIDIS ; Candice-Y JOHNSON ; Muin-J KHOURY ; Richard KING ; John MCLAUGHLIN ; David MOHER ; Andrew PATERSON ; Paul SCHEET ; Alex STEWART ; Valerie TAIT ; Cornelia VAN DUIJN ; Erik VON ELM ; George WELLS ; Miriam WIENS ; Robin-E WILLIAMSON ; Maja ZECEVIC ; Department of Epidemiology and Community Medicine. University of Ottawa. Ottawa. ON. CAN |[BDSP. Notice produite par INIST-CNRS 7JER0xrs. Diffusion soumise à autorisation]. Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this inf[...]
Article
John-Pa IOANNIDIS ; David-J BALDING ; Paolo BOFFETTA ; Anand CHOKKALINGAM ; W. DANA FLANDERS ; Siobhan-M DOLAN ; Timothy-M FRAYLING, disc. ; Julian-Pt HIGGINS ; Muin-J KHOURY ; Julian LITTLE ; Mark-I MCCARTHY ; David-H MCDERMOTT ; Thomas-R O'BRIEN ; Grier-P PAGE ; Timothy-R REBBECK ; Daniela SEMINARA ; André-G UITTERLINDEN ; Paolo VINEIS ; Department of Epidemiology and Public Health. Imperial College. London. GBR |[BDSP. Notice produite par INIST-CNRS R0xNSqfj. Diffusion soumise à autorisation]. Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guid[...]
Article
Gurdeep-S SAGOO ; Anna-M BENNET ; Adam-S BUTTER-WORTH ; John DANESH ; Ulf DE FAIRE ; Julian-Pt HIGGINS ; Jwouter JUKEMA ; John-Jp KASTELEIN ; Georgia SALANTI ; Nadeem SARWAR ; Lain TATT ; Merel VAN MAARLE ; Björn WIMAN ; Department of Public Health and Primary Care. School of Clinical Medicine. University of Cambridge. Strangeways Research Laboratory. Cambridge. GBR ; Division of Cardiovascular Epidemiology. Institute of Environmental Medicine. Karolinska Institutet. Stockholm. SWE ; United Kingdom HuGenet Coordinating Centre. Strangeways Research Laboratory. Cambridge. GBR |[BDSP. Notice produite par INIST-CNRS 88IAER0x. Diffusion soumise à autorisation]. Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD). The authors assessed associations [...]
Article
Turning the pump handle : Evolving methods for integrating the evidence on gene-disease association.
Julian-Pt HIGGINS ; Betsy ANAGNOSTELIS ; Molly-S BRAY ; Adam-S BUTTERWORTH ; John DANESH ; Carol DEZATEUX ; John-E GALLACHER ; Marta GWINN ; John-Pa IOANNIDIS ; Muin-J KHOURY ; Sarah-J LEWIS ; Julian LITTLE ; Teri-A MANOLIO ; Cosetta MINELLI ; Paul-D PHAROAH ; Georgia SALANTI ; Simon SANDERSON ; Liam SMEETH ; Lesley-A Smith ; Jonathan-A STERNE ; Emanuela TAIOLI ; John-R THOMPSON ; Simon-G THOMPSON ; Neil WALKER ; Ron-L ZIMMERN ; Department of Hygiene and Epidemiology. University of loannina School of Medicine. Ioannina. GRC ; Department of Public Health and Primary Care. University of Cambridge. Cambridge. GBR ; National Office of Public Health Genomics. Centers for Disease Control and Prevention. Atlanta. GA. USA |[BDSP. Notice produite par INIST-CNRS R0xhaa99. Diffusion soumise à autorisation].
Article
Julian-Pt HIGGINS ; George DAVEY SMITH, préf. ; Shah EBRAHIM, préf. ; Matthias EGGER, préf. ; David-J SPIEGELHALTER ; K.L. WOODS |[BDSP. Notice produite par INIST-CNRS 1R0x1Pz2. Diffusion soumise à autorisation]. Background There has been extensive discussion of the apparent conflict between meta-analyses and a mega-trial investigating the benefits of intravenous magnesium[...]
Article
Diana-R ELBOURNE ; Douglas-G ALTMAN ; Francois CURTIN ; George DAVEY SMITH, préf. ; Shah EBRAHIM, préf. ; Matthias EGGER, préf. ; Julian-Pt HIGGINS ; Andy VAIL ; Helen-V WORTHINGTON |[BDSP. Notice produite par INIST-CNRS aexR0xWz. Diffusion soumise à autorisation]. Background Meta-analysis of randomized controlled trials (RCTs) is usually based on trials where patients are randomized individually into two different, parallel[...]
