| Titre : | Anthropometric indices as predictors of survival in AIDS adults. Aquitaine Cohort, France, 1985-1997. (2000) |
| Auteurs : | Rodolphe Thiébaut ; Marimoutou CATHERINE ; Malvy Denis ; Francois Dabis ; Groupe d'Epidémiologie Clinique du Sida en Aquitaine Gecsa. FRA ; Unité Inserm 330. Bordeaux. FRA |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 16, n° 7, 2000) |
| Pagination : | 633-639 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; Poids corporel ; Pronostic ; Mortalité ; Survie ; Evolution ; Adulte ; Homme ; France ; Europe ; Epidémiologie ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST Y3yAR0xG. Diffusion soumise à autorisation]. The aim of the study was to assess the performance of weight related nutritional markers [reported involuntary weight loss (WL) greater than 10%, measured WL and body mass index (BMI) ] in predicting survival at AIDS stage. The three anthropometric indices were used as time dependant variables in Cox models to predict survival at AIDS stage. The studied sample included 630 HIV1-infected individuals of a prospective cohort of those 421 died (median survival at AIDS stage : 19.9 months). After adjustment for usual prognostic factors of survival, the reported WL greater than 10% was a pejorative predictor of survival (hazard ratio (HR) 2.4 ; 95% confidence interval (CI) : 1.9-3.0). For measured WL<5%, between 5 and 10% and >= 10% of baseline weight compared with no WL, HR were respectively, 1.9 (CI : 1.4-2.6), 3.3 (CI : 2.4-4.4) and 6.7 (CI : 5.2-8.6). The HR of death were 2.2 (CI : 1.6-3.0) for BMI between 16 and 18.4 kg/m2 and 4.4 (CI : 3.1-6.3) for BMI<16 compared to normal BMI (>= 18.5). Even a limited WL measured at a given point in time during follow up increases the risk of death at the AIDS stage. Simple cross-sectional measures of BMI have a good predictive value of survival. |
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