| Titre : | Prospective study of hepatitis B and C viral infections, cigarette smoking, alcohol consumption, and other factors associated with hepatocellular carcinoma risk in Japan. (2000) |
| Auteurs : | Mitsuru MORI ; Megumi HARA ; Toshiya HARA ; Morisada HONDA ; Junichi NARAMOTO ; Ikuko WADA ; Kyosuke YAMAMOTO ; Department of Community Health Science. Saga Medical School. Saga. JPN ; Department of Internal Medicine. Saga Medical School. Saga. JPN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 151, n° 2, 2000) |
| Pagination : | 131-139 |
| Langues: | Anglais |
| Mots-clés : | Hépatite virale B ; Virose ; Infection ; Hépatite virale C ; Tabagisme ; Condition vie ; Consommation ; Boisson alcoolisée ; Alcool ; Epidémiologie ; Facteur risque ; Homme ; Japon ; Asie ; Etude prospective ; Appareil digestif [pathologie] ; Foie [pathologie] ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST f5R0xOx6. Diffusion soumise à autorisation]. This community-based prospective study examined the effects of viral infections and lifestyle habits on hepatocellular carcinoma (HCC) risk in Japan. A baseline survey was conducted for 981 males and 2,078 females in June 1992 and evaluated hepatitis B surface antigen, second-generation hepatitis C virus antibody, and history of cigarette smoking and habitual alcohol consumption. By March 1997,14 males and 8 females had been newly diagnosed with HCC. After controlling for gender and age by using the Cox model, the authors found that positivity for hepatitis B surface antigen (hazard ratio=7.28,95% confidence interval : 1.62,32.61 ; p<0.01) and positivity for high-titer hepatitis C virus antibody (hazard ratio=40.38,95% confidence interval : 11.71,139.21 ; p<0.001) were significantly associated with HCC risk, although a history of smoking or alcohol consumption was not significantly related to risk. There was a significant interaction on an additive scale for the risk of HCC development between high-titer hepatitis C virus antibody status and a history of smoking (p<0.05) in spite of no significant interaction on a multiplicative scale. Although preventing the transmission of hepatitis viruses is most important for reducing the risk of HCC, intervention regarding lifestyle habits such as cigarette smoking should not go unheeded. |
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