| Titre : | Incidence of transitional cell carcinoma and arsenic in drinking water : A follow-up study of 8,102 residents in an Arseniasis-endemic area in Northeastern Taiwan. (2001) |
| Auteurs : | Hung-Yi CHIOU ; Chien-Jen CHEN ; Shu-Ti CHIOU ; Yi-Li CHOU ; Yi-Hsiang HSU ; Chin-Hsiao TSENG ; Min-Li WEI ; School of Public Health. Taipei Medical University. Taipei. TWN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 153, n° 5, 2001) |
| Pagination : | 411-423 |
| Langues: | Anglais |
| Mots-clés : | Pollution eau ; Eau [boisson] ; Dose effet ; Exposition ; Long terme ; Cancer ; Epidémiologie ; Facteur risque ; Incidence ; Homme ; Taiwan ; Asie ; Appareil urinaire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST SjY7R0xc. Diffusion soumise à autorisation]. A significant association between ingested arsenic and bladder cancer has been reported in an arseniasis-endemic area in southwestern Taiwan, where many households share only a few wells in their villages. In another arseniasis-endemic area in northeastern Taiwan, each household has its own well for obtaining drinking water. In 1991-1994, the authors examined risk of transitional cell carcinoma (TCC) in relation to ingested arsenic in a cohort of 8,102 residents in northeastern Taiwan. Estimation of each study subject's individual exposure to inorganic arsenic was based on the arsenic concentration in his or her own well water, which was determined by hydride generation combined with atomic absorption spectrometry. Information on duration of consumption of the well water was obtained through standardized questionnaire interviews. The occurrence of urinary tract cancers was ascertained by follow-up interview and by data linkage with community hospital records, the national death certification profile, and the cancer registry profile. Cox proportional hazards regression analysis was used to estimate multivariate-adjusted relative risks and 95% confidence intervals. There was a significantly increased incidence of urinary cancers for the study cohort compared with the general population in Taiwan (standardized incidence ratio=2.05 ; 95% confidence interval (CI) : 1.22,3.24). (...) |
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