Multivariate logistic regression for familial aggr... Catalogue en ligne

Titre :	Multivariate logistic regression for familial aggregation of two disorders. I. Development of models and methods. (2001)
Auteurs :	James-I HUDSON ; Rebecca-A BETENSKY ; Nan-M LAIRD ; Department of Biostatistics. Harvard School of Public Health. Boston. MA. USA ; Department of Psychiatry. Harvard Medical School. Boston. MA. USA
Type de document :	Article
Dans :	American journal of epidemiology (vol. 153, n° 5, 2001)
Pagination :	500-505
Langues:	Anglais
Mots-clés :	Famille ; Epidémiologie ; Méthodologie ; Homme
Résumé :	[BDSP. Notice produite par INIST de9R0xf9. Diffusion soumise à autorisation]. The question of whether two disorders cluster together, or coaggregate, within families often arises. This paper considers how to analyze familial aggregation of two disorders and presents two multivariate logistic regression methods that model both disorder outcomes simultaneously. The first, a proband predictive model, predicts a relative's outcomes (the presence or absence of each of the two disorders) by using the proband's disorder status. The second, a family predictive model derived from the quadratic exponential model, predicts a family member's outcomes by using all of the remaining family members'disorder statuses. The models are more realistic, flexible, and powerful than univariate models. Methods for estimation and testing account for the correlation of outcomes among family members and can be implemented by using commercial software.

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