Titre : | Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E epsilon2/epsilon3/epsilon4 genotype. (2003) |
Auteurs : | Bernard KEAVNEY ; Sarah CLARK ; Rory COLLINS ; John DANESH ; Marc DELEPINE ; Mark LATHROP ; Colin MCKENZIE ; Alison PALMER ; Sarah PARISH ; Richard PETO ; Linda YOUNGMAN ; Centre National de Génotypage. Paris. FRA ; Clinical Trial Service Unit and Epldemlological Studies Unit. University of Oxford. Oxford. GBR |
Type de document : | Article |
Dans : | Lancet (The) (vol. 361, n° 9355, 2003) |
Pagination : | 396-398 |
Langues: | Anglais |
Mots-clés : | Tabagisme ; Cardiopathie coronaire ; Facteur risque ; Epidémiologie ; Homme ; Infarctus ; Myocarde ; Appareil circulatoire [pathologie] ; Myocarde [pathologie] |
Résumé : | [BDSP. Notice produite par INIST-CNRS vkXFR0x7. Diffusion soumise à autorisation]. Results from two small studies, involving a total of only 174 cases, have suggested that the increased risk of coronary heart disease conferred by cigarette smoking Is substantially affected by genotype at the apolipoprotein E (APOE) epsilon2/epsilon3/epsilon4 polymorphism. We have established APOE genotypes in 4484 patients with acute myocardial infarction diagnosed before the age of 55 years for male and 65 years for female patients, and in 5757 controls with no history of cardiovascular disease. On average, the hazard ratio for myocardial infarction was 1-17 (95% Cl 1.09-1.25 ; p |