Ascertainment bias in family-based case-control st... Catalogue en ligne

Titre :	Ascertainment bias in family-based case-control studies. (2002)
Auteurs :	Kimberly-D SIEGMUND ; Bryan LANGHOLZ
Type de document :	Article
Dans :	American journal of epidemiology (vol. 155, n° 9, 2002)
Pagination :	875-880
Langues:	Anglais
Mots-clés :	Biais ; Relation familiale ; Epidémiologie ; Méthodologie ; Homme ; Enquête cas témoin
Résumé :	[BDSP. Notice produite par INIST-CNRS gw3XsR0x. Diffusion soumise à autorisation]. In a family-matched case-control study, a population-based sample of cases is selected from a well-defined geographic region over a fixed period of time. For diseases of adult onset, the control is generally a sibling or cousin who is matched on sex and age without regard to location of residence. Such a design can lead to biased estimates of environmental relative risk if the prevalence of an environmental risk factor varies by the geographic region from which the cases and controls are drawn. However, assuming the independence of genotype and environmental exposure, the estimators for the gene and gene-environment interaction effects are consistent. This suggests that we must use caution in interpreting parameters that estimate environmental main effects from a family-based case-control study if controls are selected from outside the case-ascertainment region.

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