| Titre : | Dose response of laboratory markers to alcohol consumption in a general population. (2000) |
| Auteurs : | Pekka SILLANAUKEE ; Hannu ALHO ; John-P ALLEN ; Pekka JOUSILAHTI ; Nuria Massot ; U.L.F. OLSSON ; Kari POIKOLAINEN ; Maritta PONNIO ; Jouko SUNDVALL ; Erkki VARTIAINEN ; Alcohol-related Diseases. Pharmacia & Upjohn Diagnostics Ab. Uppsala. SWE ; Dept of Epidemiology and Health Promotion. National Public Health Institute. Helsinki. FIN ; Dept of Mental Health and Alcohol Research. National Public Health Institute. Helsinki. FIN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 152, n° 8, 2000) |
| Pagination : | 747-751 |
| Langues: | Anglais |
| Mots-clés : | Consommation ; Boisson alcoolisée ; Alcool ; Alcoolisme ; Homme |
| Résumé : | [BDSP. Notice produite par INIST 8CR0x3ty. Diffusion soumise à autorisation]. The dose response to alcohol use of carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and their combination (y-CDT) was studied in an age-and gender-stratified, random sample from Finland in 1997. A linear association with a threshold between alcohol consumption and the three markers was observed. Body mass index was negatively associated with CDT and positively with GGT. Age was positively associated with GGT and gamma-CDT. In conclusion, CDT appears to be an early phase marker of alcohol consumption. The combined marker, gamma-CDT, was less associated with factors such as body mass index but more strongly correlated with alcohol consumption than were the two markers separately. |
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