| Titre : | Lead content of calcium supplements. (2000) |
| Auteurs : | Edward-A ROSS ; Nancy-J SZABO ; Ian-R TEBBETT ; Analytical Toxicology Core Laboratory. Department of Physiological Sciences. College of Veterinary Medicine. University of Florida. Gainesville. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 284, n° 11, 2000) |
| Pagination : | 1425-1429 |
| Langues: | Anglais |
| Mots-clés : | Ostéoporose ; Prévention thérapeutique ; Supplémentation ; Calcium ; Pollution chimique ; Médicament ; Plomb ; Homme ; Système ostéoarticulaire [pathologie] ; Ostéopathie |
| Résumé : | [BDSP. Notice produite par INIST iDR0xAbg. Diffusion soumise à autorisation]. Context Substantial quantities of lead have been reported in some over-the-counter calcium supplement preparations, including not only bonemeal and dolomite, but also over-the-counter natural and refined calcium carbonate formulations. Examination of this issue is warranted given recent increases in physician recommendations for calcium supplements for prevention and treatment of osteoporosis. Objectives To determine the lead content of calcium supplements and to quantify the lead exposure from popular brands of calcium in dosages used for childhood recommended daily allowance, osteoporosis, and phosphate binding in dialysis patients. Design and Setting Analysis of lead content in 21 formulations of nonprescription calcium carbonate (including 7 natural [ie, oyster shell] and 14 refined), 1 brand of prescription-only calcium acetate, and 1 noncalcium synthetic phosphate binder conducted in March 2000. Main Outcome Measures Lead content, assayed using electrothermal atomic absorption, expressed as micrograms of lead per 800 mg/d of elemental calcium, per 1500 mg/d of calcium, and for a range of dosages for patients with renal failure. Six pg/d of lead was considered the absolute dietary limit, with no more than 1 mug/d being the goal for supplements. Results Four of 7 natural products had measurable lead content, amounting to approximately 1 pg/d for 800 mg/d of calcium, between 1 and 2 pg/d for 1500 mg/d of calcium, and up to 10 mug/d for renal dosages. (...) |
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