| Titre : | Risk of gestational hypertension in relation to folic acid supplementation during pregnancy. (2002) |
| Auteurs : | Sonia HERNANDEZ-DIAZ ; Carol LOUIK ; Allen-A MITCHELL ; Martha-M WERLER ; Slone Epidemiology Center. Boston University School of Public Health. Boston. MA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 156, n° 9, 2002) |
| Pagination : | 806-812 |
| Langues: | Anglais |
| Mots-clés : | Homme ; Femme ; Grossesse ; Hypertension artérielle ; Supplémentation ; Thérapeutique ; Prévention santé ; Gestation [pathologie] ; Toxémie gravidique ; Appareil circulatoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xuHK4W. Diffusion soumise ... autorisation]. The authors investigated the association between folic acid supplementation and gestational hypertension. The study population included women with nonmalformed infants in the United States and Canada who were participating in the Slone Epidemiology Center Birth Defects Study between 1993 and 2000. Women were interviewed within 6 months after delivery about sociodemographic and medical factors, the occurrence of hypertension with or without preeclampsia, and multivitamin use in pregnancy. Relative risks, adjusted for weight, parity, twin pregnancy, diabetes, smoking, education, and family income, were estimated using Cox regression models. Of 2,100 women, 204 (9.7%) reported gestational hypertension (onset after the 20th week of gestation). The multivariate-adjusted relative risk of developing gestational hypertension during the month after folic acid supplementation, compared with not using folic acid during that same month, was 0.55 (95% confidence interval : 0.39,0.79). This finding suggests that folic acid-containing multivitamins may reduce the risk of gestational hypertension. |
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