| Titre : | Use of multiple imputation to correct for nonresponse bias in a survey of urologic Symptoms among African-American men. (2002) |
| Auteurs : | Jeremy-Mg TAYLOR ; Kristine-L COOPER ; Steve-G HEERINGA ; Trivellore-E RAGHUNATHAN ; Aruna-V SARMA ; John-T WEI ; Department of Biostatistics. University of Michigan. Ann Arbor. MI. USA ; Department of Urology. University of Michigan. Ann Arbor. MI. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 156, n° 8, 2002) |
| Pagination : | 774-782 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Prostate ; Homme ; Ethnie ; Dépistage ; Epidémiologie ; Etats Unis ; Amérique ; Méthodologie ; Questionnaire ; Appareil urinaire [pathologie] ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS qR0xsk1D. Diffusion soumise ... autorisation]. The Flint Men's Health Study is an ongoing population-based study of African-American men designed to address questions related to prostate cancer and urologic symptoms. The initial phase of the study was conducted in 1996-1997 in two stages : an interviewer-administered survey followed by a clinical examination. The response rate in the clinical examination phase was 52%. Thus, some data were missing for clinical examination variables, diminishing the generalizability of the results to the general population. This paper is a case study demonstrating the application of multiple imputation to address important questions related to prostate cancer and urologic symptoms in a data set with missing values. On the basis of the observed clinical examination data, the American Urological Association Symptoms Score showed a surprising reduction in symptoms in the oldest age group, but after multiple imputation there was a monotonically increasing trend with age. It appeared that multiple imputation corrected for nonresponse bias associated with the observed data. For other outcome measures-namely, the age-adjusted 95th percentile of prostate-specific antigen level and the association between urologic symptoms and prostate volume-results from the observed data and the multiply imputed data were similar. |
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