| Titre : | Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment. (2000) |
| Auteurs : | W.S. CUTFIELD ; K. ALBERTSSON-WIKLAND ; H. BENNMARKER ; P. CHATELAIN ; D.A. PRICE ; M.B. RANKE ; P. WILTON ; Pharmacla and Upjohn. Stockholm. SWE |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 355, n° 9204, 2000) |
| Pagination : | 610-613 |
| Langues: | Anglais |
| Mots-clés : | Diabète ; Incidence ; Hormone croissance ; Thérapeutique ; Thérapeutique médicamenteuse ; Facteur risque ; Enfant ; Homme ; Epidémiologie ; Résultat ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST ZR0x0xGJ. Diffusion soumise à autorisation]. Background Growth hormone (GH) contributes to insulin resistance, but whether children treated with GH are at increased risk of diabetes has not been established. We undertook a retrospective analysis of data from an international pharmacoepidemiological survey of children treated with GH to find out the incidence of impaired glucose tolerance and types 1 and 2 diabetes mellitus. Methods Reports to the survey of abnormal glucose metabolism were investigated and classified. The incidence and age-distribution of type 1 diabetes were compared with values from a model of reference data. The incidence of type 2 diabetes was compared with data from two reports of children not treated with GH. Findings 85 (0.36%) of 23 333 children were reported with abnormal glucose metabolism. After investigation, 43 had confirmed glucose disorders (11 with type 1 diabetes, 18 with type 2 diabetes, and 14 with impaired glucose tolerance). The incidence and age at diagnosis of type 1 diabetes in children treated with GH did not differ from expected values. The incidence of type 2 diabetes was 34.4 cases per 100 000 years of GH treatment which was six-fold higher than reported in children not treated with GH. Type 2 diabetes did not resolve after GH therapy was stopped. Interpretation GH treatment did not affect the incidence of type 1 diabetes mellitus in any age group. (...) |
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