| Titre : | Angiotensin II receptor antagonists. (2000) |
| Auteurs : | M. BURNIER ; H.R. BRUNNER ; Division of Hypertension and Vascular Medicine. Department of Medicine. Centre Hospitalier Universitaire Vaudois. Lausanne. CHE |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 355, n° 9204, 2000) |
| Pagination : | 637-645 |
| Langues: | Anglais |
| Mots-clés : | Cardiopathie ; Thérapeutique médicamenteuse ; Pharmacologie ; Pharmacocinétique ; Thérapeutique ; Sécurité ; Tolérance ; Homme ; Appareil circulatoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST C4iGmR0x. Diffusion soumise à autorisation]. Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of cardiovascular disease with specific pharmacological probes. Oral activity, achieved by shortening the original peptide structures, transformed the probes into therapeutic agents, the angiotensin-converting enzyme (ACE) inhibitors. However, ACE is a non-specific target for blocking the renin-angiotensin enzymatic cascade. The availabillty of orally active drugs turned ACE inhibition into a therapeutic breakthrough but more specific blockade always seemed desirable. This goal has now been achieved with the orally active angiotensin II receptor antagonists ; six are on the market and more are under development. This new class of drugs is equal in effiçacy to ACE inhibitors, at least in hypertensive patients. Trials now underway will demonstrate whether angiotensin II receptor antagonists can prevent target-organ damage and reduce cardiovascular morbidity and mortality. If they do, these compounds might one day replace ACE inhibitors. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact