| Titre : | Menopausal estrogen and estrogen-progestin replacement therapy and Breast Cancer risk. (2000) |
| Auteurs : | C. SCHAIRER ; L. BRINTON ; R. HOOVER ; J. LUBIN ; S. STURGEON ; R. TROISI ; National Cancer Institute. Division of Cancer Epidemiology and Genetics. Rockville. MD. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 283, n° 4, 2000) |
| Pagination : | 485-491 |
| Langues: | Anglais |
| Mots-clés : | Ménopause ; Association thérapeutique ; Sein ; Dépistage ; Facteur risque ; Etude comparée ; Résultat ; Femme ; Homme ; Cancer ; Glande mammaire [pathologie] ; Prévention santé |
| Résumé : | [BDSP. Notice produite par INIST 19QHR0xH. Diffusion soumise à autorisation]. Context Whether menopausal hormone replacement therapy using a combined estrogen-progestin regimen increases risk of breast cancer beyond that associated with estrogen alone is unknown. Objective To determine whether increases in risk associated with the estrogen-progestin regimen are greater than those associated-with estrogen alone. Design Cohort study of follow-up data for 1980-1995 from the Breast Cancer Detection Demonstration Project, a nationwide breast cancer screening program. Setting Twenty-nine screening centers throughout the United States. Participants A total of 46 355 postmenopausal women (mean age at start of follow-up, 58 years). Main Outcome Measure Incident breast cancers by recency, duration, and type of hormone use. Results During follow-up, 2082 cases of breast cancer were identified. Increases in risk with estrogen only and estrogen-progestin only were restricted to use within the previous 4 years (relative risk [RR], 1.2 [95% confidence interval {CI}, 1.0-1.4] and 1.4 [95% CI, 1.1-1.8], respectively) ; the relative risk increased by 0.01 (95% CI, 0.002-0.03) with each year of estrogen-only use and by 0.08 (95% CI, 0.02-0.16) with each year of estrogen-progestin-only use among recent users, after adjustment for mammographic screening, age at menopause, body mass index (BMI), education, and age. The P value associated with the test of homogeneity of these estimates was. 02. Among women with a BMI of 24. (...) |
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