| Titre : | Resistance to reinfection with Schistosoma mansoni in occupationally exposed adults and effect of HIV-1 co-infection on susceptibility to schistosomiasis : a longitudinal study. (2002) |
| Auteurs : | Diana-Ms KARANJA ; Julius ANDOVE ; Daniel-G COLLEY ; Karin GALIL ; Allen-W HIGHTOWER ; Pauline-Nm MWINZI ; Wevan SECOR ; Centre for Vector Biology and Control Research. Kenya Medical Research Institute. Kisumu. KEN ; Division of Parasitic Diseases. National Center for Infectious Diseases. Centers for Disease Control and Prevention. Public Health Service. Us Department of Health and Human Services. Atlanta. GA. USA |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 360, n° 9333, 2002) |
| Pagination : | 592-596 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; VIH ; Rétrovirus ; Virus ; Bilharziose ; Parasitose ; Activité professionnelle ; Epidémiologie ; Facteur risque ; Homme ; Médecine travail ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS IkDrR0xz. Diffusion soumise à autorisation]. Background Previous studies have reported age-dependent development of resistance to reinfection by schistosomes and identified immunological correlates of this resistance. However, whether resistance exists that is independent of age effects has been questioned. We did a longitudinal investigation of reinfection by Schistosoma mansoni in an adult population with high occupational exposure. Methods We monitored a cohort of 96 male car washers working along the shores of Lake Victoria, Kenya during 349.7 person-years for frequency of water contact and infection with S mansoni. Patients were treated with praziquantel upon study entry and after reinfection with S mansoni. Bivariate analyses and a multivariate proportional hazards model were used to assess the effects of water contact, previous infections, and HIV-1 on S mansoni reinfection rates. Findings 13 car washers did not get reinfected or only became reinfected after an extended time (91 weeks). 47 initially had a short time to reinfection (15 weeks) but on subsequent treatments showed increased time to reinfection (29-38 weeks). 36 consistently displayed short times to reinfection (<15 weeks) despite multiple reinfection and treatment cycles. Decreased CD4 T-cell counts in HIV-1-positive individuals corresponded to increased susceptibility to S mansoni reinfection. Interpretation Adults similarly exposed to schistosomiasis are either resistant to reinfection ; susceptible, but develop resistance to reinfection after multiple treatments ; or remain susceptible to reinfection. Thus, immunological resistance to reinfection with S mansoni exists or can develop independent of age effects. The consequence of HIV-1 co-infection suggests that CD4 T cells contribute to this resistance. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact