| Titre : | Risk of specific birth defects in relation to chlorination and the amount of natural organic matter in the water supply. (2002) |
| Auteurs : | Bing-Fang HWANG ; Jouni-Jk JAAKKOLA ; Per MAGNUS ; Department of Epidemiology. The Johns Hopkins Bloomberg School of Public Health. Baltimore MD. TWN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 156, n° 4, 2002) |
| Pagination : | 374-382 |
| Langues: | Anglais |
| Mots-clés : | Malformation ; Nouveau né ; Homme ; Epidémiologie ; Facteur risque ; Désinfection ; Exposition ; Chlore ; Pollution eau ; Système nerveux [pathologie] ; Appareil circulatoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 8R0xYRKh. Diffusion soumise à autorisation]. To assess the effect of water chlorination by-products on specific birth defects, the authors conducted a nationwide cross-sectional study of 285,631 Norwegian births in 1993-1998. Risks of birth defects according to four chlorination by-product exposure categories were compared on the basis of chlorination (yes/no) and level of water color (mg Pt/liter), representing the amount of natural organic matter : high (chlorination,<20), medium (chlorination, 10-19.9), and low (chlorination,<10) exposure, with no chlorination and low color (<10) as the reference category. In logistic regression analysis, the risks of any birth defect (adjusted odds ratio (OR)=1.13,95% confidence interval (Cl) : 1.01,1.25) and of cardiac (adjusted OR=1.37,95% Cl : 1.00,1.89), respiratory system (adjusted OR=1.89,95% Cl : 1.00,3.58), and urinary tract (adjusted OR=1.46,95% Cl : 1.00,2.13) defects were significantly associated with exposure (medium and high combined). Regarding risk of specific birth defects, only that for ventricular septal defects was significantly elevated, with an exposure-response pattern, yielding adjusted odds ratios of 1.63 (95% Cl : 1.02,2.58) for the medium and 1.81 (95% Cl : 1.05,3.09) for the high exposure categories. Furthermore, risk of neural tube defects was related to high color (adjusted OR=2.60,95% Cl : 1.30,5.26). |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact