| Titre : | Prognostic value of clinical variables in ovarian cancer. (1997) |
| Auteurs : | P. DISILVESTRO ; C.O. GRANAI ; J.W. HOGAN ; J.F. PEIPERT ; Institute for Clinical Evaluative Sciences. Toronto. CAN |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 50, n° 5, 1997) |
| Pagination : | 501-505 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Mortalité ; Survie ; Pronostic ; Symptôme ; Homme ; Etats Unis ; Amérique ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST 2UsZR0xV. Diffusion soumise à autorisation]. Objective : To test the hypothesis that clinical variables, including the patient's symptoms, symptom severity, and co-morbidity, affect the survival rate in patients with ovarian cancer. Methods : We reviewed the records of 137 cases of ovarian cancer diagnosed and treated between January 1987 and June 1992, and extracted data regarding patients'demographic characteristics, symptoms, medical co-morhidity, stage of disease, tumor histology and grade, treatment, and clinical course. Results : Once cases of borderline tumors were excluded, the overall 3-year and 4-year mortality rate were 38% and 49%, respectively. There was an decrease in 4-year survival with more advanced symptom type ranging from 85% in asymptomatic women to 38% in women with complex symptoms (log rank, p=0.005). Medical co-morbidity was not found to affect survival in the cohort studied. We performed multivariable analysis using a Cox proportional hazards model and confirmed that the symptom stage was highly prognostic even after controlling for FIGO stage, age, and co-morbidity (p=0.004). Conclusion : We found that clinical variables, such as patient's symptoms, were associated with prognosis. Symptom classification is a necessary and important component in a system of prognostic stratification for ovarian cancer. |
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