| Titre : | Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men : The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. (1997) |
| Auteurs : | P. PIETINEN ; D. ALBANES ; A. ASCHERIO ; A.M. HARTMAN ; P. KORHONEN ; J. VIRTAMO ; W.C. Willett ; Department of Family Medicine and Clinical Epidemiology. School of Medicine. University of Pittsburgh. Pittsburgh. PA. USA ; Division of General Medicine. Brigham and Women's Hospital. Boston. MA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 145, n° 10, 1997) |
| Pagination : | 876-887 |
| Langues: | Anglais |
| Mots-clés : | Cardiopathie coronaire ; Mortalité ; Epidémiologie ; Consommation alimentaire ; Comportement alimentaire ; Lipide ; Homme ; Finlande ; Europe ; Appareil circulatoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST UAvoR0xy. Diffusion soumise à autorisation]. The relation of intakes of specific fatty acids and the risk of coronary heart disease was examined in a cohort of 21,930 smoking men aged 50-69 years who were initially free of diagnosed cardiovascular disease. All men participated in the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and completed a detailed and validated dietary questionnaire at baseline. After 6.1 years of follow-up from 1985-1988, the authors documented 1,399 major coronary events and 635 coronary deaths. After controlling for age, supplement group, several coronary risk factors, total energy, and fiber intake, the authors observed a significant positive association between the intake of trans-fatty acids and the risk of coronary death. For men in the top quintile of trans-fatty acid intake (median=6.2 g/day), the multivariate relative risk of coronary death was 1.39 (95% confidence interval (Cl) 1.09-1.78) (p for trend=0.004) as compared with men in the lowest quintile of intake (median=1.3 g/day). The intake of omega-3 fatty acids from fish was also directly related to the risk of coronary death in the multivariate model adjusting also for trans-saturated and cis-monounsaturated fatty acids (relative risk (RR)=1.30,95% Cl 1.01-1.67) (p for trend=0.06 for men in the highest quintile of intake compared with the lowest). (...) |
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