Résumé :
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[BDSP. Notice produite par INIST 0FR0xTc7. Diffusion soumise à autorisation]. Background. In order to investigate whether an earlier reported association between maternal smoking during pregnancy and urinary organ malformations could be confirmed, a study was made using Swedish health registries. Methods. Infants with kidney malformations (n=483) and infants with other urinary organ malformations with no primary involvement of the kidney (s) (n=719) were selected among 1 117 021 infants born 1983-1993 with known smoking exposure in early pregnancy. Results. A moderate, statistically significant association between maternal smoking and kidney malformations was found (adjusted odds ratio [OR]=1.22,95% confidence interval [CI] : 1.00-1.48). With the exception of genetic renal polycystic disease, the main subgroups of kidney malformations showed similar OR. For other urinary organ malformations, no association with smoking could be detected (OR=0.93,95% Cl : 0.79-1.11). Conclusions. This study supports an association between maternal smoking during pregnancy and kidney malformations. No obvious confounders were detected but further work is needed before a causal inference can be made.
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