| Titre : | Does age at natural menopause affect mortality from ischemic heart disease ? (1997) |
| Auteurs : | B.K. JACOBSEN ; I. HEUCH ; G. KVALE ; S. NILSSEN |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 50, n° 4, 1997) |
| Pagination : | 475-479 |
| Langues: | Anglais |
| Mots-clés : | Myocarde ; Mortalité ; Epidémiologie ; Femme ; Homme ; Ménopause ; Age ; Norvège ; Europe ; Appareil circulatoire [pathologie] ; Cardiopathie coronaire ; Myocarde [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST rDjfR0x9. Diffusion soumise à autorisation]. We examined the relationship between age at natural menopause and mortality of ischemic heart disease in 19,309 Norwegian postmenopausal women. A total of 2767 fatal infarctions occurred during 29 years of follow up. Overall, a relatively weak inverse relationship was seen with approximately 10% lower ischemic heart disease mortality in women aged 47 years at the menopause compared to women with an early menopause (<44 years). Risk estimates were similar for women aged 47 and more at menopause. However, the inverse relationship was stronger and statistically significant (p=0.01) in women aged less than 70 years. In this group of women, we observed a nearly 60% reduction in the ischemic heart disease mortality in women with a late menopause ( 53 years) compared to women aged<44 years at menopause (mortality rate ratio=0.42 ; 95% confidence interval 0.25-0.72). This protective effect of a late menopause is reduced with advancing age, however, and is of minor significance in the age groups where the great proportion of the ischemic heart disease deaths occur. |
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