| Titre : | Seasonality and malaria in a West African village : Does high parasite density predict fever incidence ? (1997) |
| Auteurs : | P. BOUVIER ; N. BRESLOW ; V. DELLEY ; M. DIAKITE ; A. DICKO ; O. DOUMBO ; A. MAURIS ; C.F. Robert ; A. ROUGEMONT ; The Vancouver Hospital and Health Sciences Centre. Vancouver. BC. CAN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 145, n° 9, 1997) |
| Pagination : | 850-857 |
| Langues: | Anglais |
| Mots-clés : | Paludisme ; Parasitose ; Infection ; Epidémiologie ; Fièvre ; Enfant ; Homme ; Endémie ; Variation saisonnière ; Milieu rural ; Mali ; Afrique ; Age |
| Résumé : | [BDSP. Notice produite par INIST ABc18R0x. Diffusion soumise à autorisation]. In this cohort study, the authors studied the effect of blood malaria parasite density on fever incidence in children in an endemic area with 9 days'follow-up of 1 - to 12-year-old children during two time periods : the end of the dry season (May 1993 : n=783) and the end of the rainy season (October 1993 : n=841) in Bougoula, West Africa (region of Sikasso, Mali). The cumulative incidence of fever (temperature>38.0°C) was 2.0% in the dry season and 8.2% in the rainy season (p<0.0001). In the rainy season, the risk of fever was increased in children of ages 1-3 years (relative risk (RR)=2.5,95% confidence interval (CI) 1.6-4.1) ; in those with an initial parasitemia>15,000/mul (RR=2.7,95% CI 1.4-5.4) ; in children with an enlarged spleen (RR=2.0,95% CI 1.2-3.3) ; or in those with anemia (hematocrit<30% : RR=1.8,95% CI 1.1-2.9). In the dry season, anemia was the only predictor of fever incidence. In the rainy season, the best predictors of fever were, in order, age (<4 years), enlarged spleen, and high parasite density. Even in the higher risk groups, the cumulative incidence was<20%. The authors conclude that most children with high parasite density do not develop fever subsequently. The association between parasite density and fever varies according to age and season. (...) |
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