| Titre : | Distribution of mecA among methicillin-resistant clinical staphylococcal strains isolated at hospitals in Naples, Italy. (2003) |
| Auteurs : | E. GALDIERO ; M. D'ISANTO ; N. DAMIANO ; G. LIGUORI ; L. SOMMESE ; Dipartimento di Medicina Sperimentale - Sezione Microhiologia. Facoltà di Medicina e Chirurgia. Seconda Università di Napoli. ITA |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 18, n° 2, 2003) |
| Pagination : | 139-145 |
| Langues: | Anglais |
| Mots-clés : | Hôpital ; Italie ; Europe ; Bactérie ; Staphylococcie ; Bactériose ; Infection ; Infection nosocomiale ; Prévalence ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS j4y0aR0x. Diffusion soumise à autorisation]. Two hundred and twenty strains of Staphylococcus isolated in Naples, Italy, were surveyed for the distribution of the mecA, the structural gene for penicillin-binding protein 2a, which is the genetic determinant for methicillin-resistance in staphylococci. Screening by a cloned mecA, revealed that of 220 strains, 43 were methicillin-resistant (19.5%) and 177 were methicillin-susceptible (80.5%). Among the 43 resistant strains 23 (53.5%) carried mecA in their genome and 20 (46.5%) did not carry mecA, in spite of their resistance to methicillin. Every group was submitted to the AP-PCR profiling. A quantitative analysis of the patterns divided strains into four different clusters for methicillin-resistant mecA-negative and two different clusters for methicillin-resistant mecA-positive with primer 1, while no clusters were noted with primer 7. We conclude that these clinical isolates from our area, were not found to belong to a single clone, although the predominance of four methicillin-resistant mecA-negative genotypes were noted. |
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