| Titre : | Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany. (1995) |
| Auteurs : | D. FLESCH-JANYS ; J. Berger ; J.H. DWYER ; P. GURN ; A. MANZ ; S. NAGEL ; H. WALTSGOTT ; Cent chemical workers'health. Dep health. Hamburg. DEU |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 142, n° 11, 1995) |
| Pagination : | 1165-1175 |
| Langues: | Anglais |
| Mots-clés : | Pesticide ; Exposition professionnelle ; Industrie chimique ; Mortalité ; Homme ; Allemagne ; Europe ; Médecine travail ; Epidémiologie ; Cancer ; Appareil circulatoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST pR0xIS26. Diffusion soumise à autorisation]. The relation between mortality (all cause ; cancer ; cardiovascular diseases (International Classification of Diseases, Ninth Revision (ICD-9), codes 390-459) ; ischemic heart diseases (ICD-9 codes 410-414)) and exposure to polychlorinated dibenzo-p-dioxins and - furans (PCDD/F) was investigated in a retrospective cohort study. The cohort consisted of 1,189 male workers in a chemical plant in Hamburg, Federal Republic of Germany, who had produced phenoxy herbicides, chlorophenols, and other herbicides and insecticides known to be contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and other, higher chlorinated dioxins and furans. The authors reported previously on cancer mortality in this cohort for the follow-up period 1952-1989. The current study covers the years 1952-1992 and investigates the relation of PCDD/F exposure to mortality using a quantitative estimate of PCDD/F exposure for the whole cohort derived from blood and adipose tissue levels measured in a subgroup (n=190). Quintiles and deciles of these estimates served as dose parameters in the estimation of relative risks (RRs), using year-of-birth stratified Cox regression. An unexposed cohort of gas workers served as an external reference group. The total mortality was elevated in all dose groups. These findings indicate a strong dose-dependent relation between mortality due to cancer or ischemic heart diseases and exposure to polychlorinated dioxins and furans. |
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