| Titre : | Risk factors and cofactors for human T-cell lymphotropic virus type I (HTLV-I) - associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica. (1995) |
| Auteurs : | A. KRAMER ; J. Benichou ; W.A. BLATTNER ; B. CRANSTON ; S. LARSEN ; E.M. MALONEY ; A. MANNS ; O.S.C. MORGAN ; E.L. MURPHY ; J. MURPHY ; P. RODGERS-JOHNSON ; Nih. National cancer inst. Viral epidemiology branch. Rockville MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 142, n° 11, 1995) |
| Pagination : | 1212-1220 |
| Langues: | Anglais |
| Mots-clés : | Virus ; Virose ; Infection ; Homme ; Epidémiologie ; Facteur risque ; Jamaïque ; Antilles ; Amérique ; Système nerveux [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST 5KcR0x7I. Diffusion soumise à autorisation]. Human T-cell lymphotropic virus type I (HTLV-I) has been etiologically associated with a neurologic syndrome called HTLV-I-associated myelopathy/tropical spastic paraparesis as well as with adult T-cell leukemia/lymphoma. The authors sought to quantify the risk in Jamaica of HAM/TSP associated with HTLV-I infection and cofactors associated with this disease among infected individuals. Between 1988 and 1989, prevalent and incident HAM/TSP patients and controls with other neurologic diseases were enrolled in a retrospective study. A second control group was composed of HTLV-I-seropositive, asymptomatic carriers in Jamaica, ascertained in a separate study conducted in 1988. Although HTLV-I seropositivity was not a component of the case definition for HAM/TSP, all 43 HAM/TSP patients were HTLV-I seropositive compared with two of the controls with other neurologic diseases. Given HTLV-I seropositivity, one cofactor associated with the risk of HAM/TSP was young age at initial heterosexual intercourse (odds ratio=4.00,95% confidence interval 1.29-12.46 for individuals aged 15 ; odds ratio=4.26,95% confidence interval 1.41-12.90 for individuals aged 16-17 years at initial intercourse). Neither an early age at initial sexual intercourse or the number of lifetime sexual partners was a risk factor for adult T-cell leukemia/lymphoma. These data support the hypothesis that HAM/TSP is associated with sexually acquired HTLV-I infection, whereas adult T-cell leukemia/lymphoma is not. |
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