| Titre : | Relation of sex hormones and dehydroepiandrosterone sulfate (DHEA-SO4) to cardiovascular risk factors in postmenopausal women. (1995) |
| Auteurs : | S.M. HAFFNER ; B.E.K. KLEIN ; R. Klein ; P.M. MARCUS ; P.A. NEWCOMB |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 142, n° 9, 1995) |
| Pagination : | 925-934 |
| Langues: | Anglais |
| Mots-clés : | Epidémiologie ; Facteur risque ; Appareil cardiovasculaire ; Homme ; Lipide ; Etats Unis ; Amérique |
| Résumé : | [BDSP. Notice produite par INIST 919wR0xO. Diffusion soumise à autorisation]. Sex hormones play a major role in determining the risk of cardiovascular disease. While several studies have shown that reduced sex hormone-binding globulin is associated with an atherogenic pattern of lipoproteins and increased glucose concentrations in premenopausal women, little data are available examining the association of sex hormone-binding globulin and sex hormones with cardiovascular risk factors in postmenopausal women, a group with high rates of cardiovascular disease. The investigators hypothesized that in postmenopausal women decreased sex hormone-binding globulin and increased testosterone would be associated with an atherogenic pattern of cardiovascular risk factors. The sex hormone-binding globulin, total and free testosterone, estrone, and dehydroepiandrosterone sulfate (DHEA-SO4) in 253 postmenopausal women who were not taking hormones were measured in a population-based study, the Beaver Dam Eye Study (Beaver Dam, Wisconsin, 1988-1990). Sex hormone-binding globulin was significantly inversely correlated with body mass index (r=-0.53, p<0.001), glycosylated hemoglobin (r=-0.34, p<0.001), and diastolic blood pressure (r=-0.25, p<0.01), and positively correlated with high density lipoprotein cholesterol (HDL cholesterol) (r=0.31, p<0.001), and HDL cholesterol/total cholesterol (r=0.31, p<0.001). Total (r=-0.20, p<0.01) and free (r=-0.14, p<0.05) testosterone were significantly inversely correlated with HDL cholesterol/total cholesterol ratio. |
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