| Titre : | Respiratory illness, bêta-agonists, and risk of idiopathic dilated cardiomyopathy : the Washington, DC, dilated cardiomyopathy study. (1995) |
| Auteurs : | S.S. COUGHLIN ; K.L. BAUGHMAN ; S. DUPRAW ; B.J. GERSH ; F.J. MATHER ; E.P. MCCARTHY ; C. METAYER ; R.E. WALDHORN ; Tulane univ school public health tropical medicine. Dep biostatistics epidemiology. New Orleans LA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 142, n° 4, 1995) |
| Pagination : | 395-403 |
| Langues: | Anglais |
| Mots-clés : | Epidémiologie ; Appareil respiratoire [pathologie] ; Association ; Homme ; Thérapeutique médicamenteuse ; Thérapeutique ; Etats Unis ; Amérique ; Appareil circulatoire [pathologie] ; Cardiopathie ; Myocarde [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST R0xvzRkm. Diffusion soumise à autorisation]. An epidemiologic study was carried out to examine the possible role of bêta-agonists and other respiratory medications in the development of idiopathic dilated cardiomyopathy. Associations with respiratory medications, bronchial asthma, emphysema, and chronic bronchitis were examined by comparing newly diagnosed cases (n=129) ascertained from five Washington, DC, area hospitals for the period 1990-1992 with neighborhood controls (n=258) identified by using a random digit dialing technique. The cases and controls were matched on sex and 5-year age intervals and were compared in the analysis using conditional logistic regression methods. A statistically significant association was observed between idiopathic dilated cardiomyopathy and history of emphysema or chronic bronchitis (adjusted odds ratio (OR)=4.4,95% confidence interval (01) 1.6-12.4). The association with bronchial asthma was of borderline significance (adjusted OR=1.9,95% Cl 0.9-4.2). Associations were also observed with use of oral bêta-agonists (adjusted OR=3.4,95% CI 1.1-11.0) and bêta-agonist inhalers or nebulization (adjusted OR=3.2,95% CI 1.4-7.1), as well as with use of oral corticosteroids, inhaled corticosteroids or cromolyn, and theophylline medications. The results of this study suggest, but do not prove, that use of bêta-agonists has an etiologic role in idiopathic dilated cardiomyopathy. Am J Epidemiol 1995 ; 142 : 395-403. |
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