| Titre : | Multiple false reactions in viral antibody screening assays after influenza vaccination. (1995) |
| Auteurs : | L. SIMONSEN ; J. BUFFINGTON ; B.J. GROSSMAN ; R.C. HOLMAN ; L.B. SCHONBERGER ; C.N. SHAPIRO ; T.W. STRINE ; A.E. Williams ; Cent disease control prevention. National cent infectious diseases. Div viral rickettsial diseases. Atlanta GA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 141, n° 11, 1995) |
| Pagination : | 1089-1096 |
| Langues: | Anglais |
| Mots-clés : | Virus ; Méthode épidémiologique ; Dépistage ; Epidémiologie ; Don sang ; Homme ; Vaccination ; Grippe ; Virose ; Infection ; Etats Unis ; Amérique |
| Résumé : | [BDSP. Notice produite par INIST LUR0xMO0. Diffusion soumise à autorisation]. In December 1991, US blood centers reported an unusual increase in donations that tested falsely reactive for antibodies to two or more (multiple false positive) of the following viruses : human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotrophic virus type I (HTLV-I), and hepatitis C virus. Many of these donations were from people who had recently received the 1991-1992 influenza vaccine, raising the possibility that this vaccine had somehow specifically caused the problem of multiple false reactivity. A case-control study of 101 affected donors and 191 matched controls found that recent receipt of any brand of influenza vaccine was significantly associated with testing multiple false positive (p<0.05), as was a history of recent acute illness (p<0.05) and of allergies (p<0.05). Surveillance for monthly rates of multiple reactive donations from May 1990 through December 1992 linked the seasonal cluster of multiple false-positive donations to the use of viral screening test kits thought to react nonspecifically to donor immunoglobulin M. There was no similar increase in multiple false-positive donations during the 1992-1993 influenza vaccination season after the HIV-1 and hepatitis C virus tests were replaced ; however, the number of donations that were falsely reactive for only HTLV-I almost doubled, indicating that false reactivity was not specifically associated with the 1991-1992 influenza vaccine. |
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