| Titre : | Focus : Taking on Tobacco. Importance of attributable risk in monitoring adverse events after immunization : Hepatitis B vaccination in children. (2001) |
| Auteurs : | Gaston DE SERRES ; Nicole BOULIANNE ; Marc DIONNE ; Bernard Duval ; Monique-Douville FRADET ; Richard Masse ; Marie Rochette ; David SATCHER ; Institut National de Santé Publique du Québec (INSPQ) (Québec, CAN) ; Ministère de la Santé et des Services Sociaux du Québec. Québec. CAN ; Public Health Research Unit. Chul Research Center. Laval University. Québec. CAN |
| Type de document : | Article |
| Dans : | American journal of public health (vol. 91, n° 2, 2001) |
| Pagination : | 313-315 |
| Langues: | Anglais |
| Mots-clés : | Vaccin ; Hépatite virale B ; Virose ; Infection ; Epidémiologie ; Canada ; Amérique ; Effet secondaire ; Enfant ; Homme ; Evaluation ; Appareil digestif [pathologie] ; Foie [pathologie] ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST 0s0R0xPB. Diffusion soumise à autorisation]. Objectives. Most vaccine safety data present only the postvaccuntion incidence of all adverse events rather than an estimate of attributable risk. This study sought to illustrate the difference between the 2 estinstes with data from a hepatitis B imnamization program. Methods. The incidence of health problems occurring before and after each dose of hepatitis B vaccine in a cobort of 1130 children were compared. Results. Although 47.5% of all children reported an adverse event during the 4 weeks following each of the 3 doses, adverse events attributable to immunization occurred in only 10.6% of children. Conclusions. Postimmunization incidence systematically overestimates the risk of adverse events, Estimating actual attributable risk is recessary to avoid false attributable risk is recessary to avoid false beliets regurding immunization. |
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